منابع مشابه
The danger theory: 20 years later
The self-non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the "danger theory." This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to...
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The “danger theory” of Polly Matzinger posed in 1994 (Matzinger, 1994) principally holds that the immune system is far less concerned with “foreign” (microorganisms, cells, and molecules) than with signals that cause dangerous damage, and, furthermore, that antigen-presenting cells respond to danger signals—most notably from cells undergoing stress and/or injury—to initiate an immune response. ...
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The early mouse embryo is an excellent model to study chromatin changes that underlie zygotic gene activation. Chromatin remodelling in the fertilised mouse egg is intimately linked to protein synthesis and degradation, to protamine by histone replacement and to specific histone modifications. Roumen Tsanev made significant contributions in this field of research. He generated seminal data on p...
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The theory of abstract Case in the framework of Government and Binding played an important role in capturing cross-linguistic generalizations regarding order and constituency and accommodating exceptions to word order universals. Case was shown to be relevant even in languages without morphological case markings. Indeed, Li (1985, 1990) demonstrated that Case facilitated the understading of a w...
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The idea of diffractive processes with a hard scale involved, to resolve the underlying parton dynamics , was published 1985 and experimentally verified 1988. Today hard diffraction is an active research field with high-quality data and new theoretical models. The trend from Regge-based pomeron models to QCD-based parton level models has given insights on QCD dynamics involving perturbative glu...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2012
ISSN: 1664-3224
DOI: 10.3389/fimmu.2012.00287